PYRIMIDINE METABOLISM REGULATOR-MEDIATED MOLECULAR SUBTYPES DISPLAY TUMOR MICROENVIRONMENTAL HALLMARKS AND ASSIST PRECISION TREATMENT IN BLADDER CANCER

BackgroundBladder cancer (BLCA) is a common urinary system malignancy with a significant morbidity and death rate worldwide.Non-muscle invasive BLCA accounts for over 75% of all BLCA cases.The imbalance of tumor metabolic pathways is associated with tumor formation and proliferation.Pyrimidine metabolism (PyM) is a complex enzyme network that incor

Abrasive wear Rectangle - Acrylic Block LED Night Light is a principal cost in mining and mineral processing operations.High chromium white cast iron (WCI) further reinforced with niobium carbide (NbC) shows promise to increase component wear lives.This work investigates the effect of niobium macro-additions on microstructure, hardness and high-str

Abstract The wireless power transfer (WPT) system has neck gaiter been widely used in various fields such as household appliances, electric vehicle charging and sensor applications.A frequency reconfigurable magnetic resonant coupling wireless power transfer (MRCWPT) system with dynamically enhanced efficiency by using the frequency reconfigurable

Background: Multiple drug prescriptions in chronic kidney disease (CKD) escalate metabolic buildup, nephrotoxicity, and end stage kidney disease progression.We aimed to study polypharmacy and harmful multi-drug interactions at the nephrology department of South-Kazakhstan Regional Digital Portion Scales hospital.Methods: We analyzed electronic medi

Members of the genus Lactobacillus are commonly found at the gastrointestinal tract and other mucosal surfaces of humans.This genus includes various species with a great number of potentially probiotic bacteria.Other often-used probiotic species belong to Bifidobacterium, a genus almost exclusively associated with the gut.As probiotics must survive